A Clinical Experience to Assess Safety and Efficacy of Fixed Dose Combination of Clindamycin and Clotrimazole in the Treatment of Patients With Mixed Bacterial and Fungal Vaginosis

Abstract

Background: The aim of the study was to evaluate the safety and efficacy of clindamycin (100 mg) + clotrimazole (200 mg) suppository in the treatment of mixed bacterial and fungal vaginosis.

Method: Five hundred patients with clinical diagnosis of infective vaginosis entered this multi-center, prospective, open-label, non-comparative study. A fixed dose combination of clindamycin (100 mg) and clotrimazole (200 mg) suppository was inserted intravaginally for three nights.

Results: Symptoms of infective vaginosis decreased significantly within 3 days of treatment initiation. On day 3 of treatment, 84.8% patients had normal and odorless vaginal discharge, and the mean vaginal burning and irritation score declined by 92.4% and 94.8% respectively. Also, there was remission of vulvar, cervical and vaginal erythema in more than 85% of patients. The physicians and patients rated treatment efficacy as good to very good improvement and tolerability to the treatment was regarded as good to excellent. No serious adverse events were reported.

Conclusion: The present study demonstrates that the fixed dose combination of clindamycin and clotrimazole is effective and well tolerated in the treatment of mixed vaginosis due to bacterial and fungal origin.




J Clin Gynecol Obstet. 2015;4(2):217-225
doi: http://dx.doi.org/10.14740/jcgo331w